5 Best Male Enhancement Supplements for General Sexual Wellness

For ED, labeling starts at 2.5 mg once daily and permits 5 mg according to response and tolerability. Take at roughly the same time each day, regardless of sex or meals. Daily 5 mg also treats BPH symptoms. Steady-state levels are reached within about 5 days, not a guaranteed time to benefit. Sexual stimulation is required. Do not add an extra as-needed dose. Daily use is not recommended in severe renal impairment. Common effects include headache, indigestion and back/muscle pain; heavy drinking increases low-blood-pressure risk.

Prescription required in the U.S.; a clinician must assess suitability and choose the dose. Never combine with nitrates, nitrite 'poppers', or riociguat. Review heart health, kidney/liver disease, alpha-blockers, blood-pressure medicines and CYP3A4 interactions. Do not combine ED medicines. Get emergency care for an erection lasting over 4 hours; stop use and seek prompt care for sudden vision/hearing loss. For chest pain during sex, stop and get urgent care; tell responders when the last dose was taken.

Typical label dose: 10 mg before sex; a prescriber may select 5–20 mg. Take at least 30 minutes beforehand, at most once daily for most patients. May improve erectile response for up to 36 hours; this does not mean a continuous erection. Food does not affect absorption. Sexual stimulation is required; it does not increase desire. Common effects include headache, indigestion, flushing, back/muscle pain and nasal congestion. Heavy drinking can worsen low blood pressure.

Prescription required in the U.S.; a clinician must assess suitability and choose the dose. Never combine with nitrates, nitrite 'poppers', or riociguat. Review heart health, kidney/liver disease, alpha-blockers, blood-pressure medicines and CYP3A4 interactions. Do not combine ED medicines. Get emergency care for an erection lasting over 4 hours; stop use and seek prompt care for sudden vision/hearing loss. For chest pain during sex, stop and get urgent care; tell responders when the last dose was taken.

Label strengths: 25, 50 and 100 mg. The usual starting dose is 50 mg about 1 hour before sex, adjusted by the prescriber; the labeled timing range is 30 minutes to 4 hours beforehand. Maximum once daily for most patients. A high-fat meal may delay onset. Sexual stimulation is required; it does not increase desire. Common effects include headache, flushing, indigestion, nasal congestion and temporary visual changes.

Prescription required in the U.S.; a clinician must assess suitability and choose the dose. Never combine with nitrates, nitrite 'poppers', or riociguat. Review heart health, kidney/liver disease, alpha-blockers, blood-pressure medicines and CYP3A4 interactions. Do not combine ED medicines. Get emergency care for an erection lasting over 4 hours; stop use and seek prompt care for sudden vision/hearing loss. For chest pain during sex, stop and get urgent care; tell responders when the last dose was taken.

As needed: typically 10 mg at least 30 minutes before sex, adjusted to 5–20 mg, at most once daily for most patients; response may last up to 36 hours. Daily ED labeling starts at 2.5 mg and may increase to 5 mg, though the current U.S. brand label lists marketed tablets of 5, 10 and 20 mg. Daily 5 mg also treats BPH symptoms. Meals do not affect absorption; sexual stimulation remains necessary. Common effects include headache, indigestion and back/muscle pain. Heavy alcohol use increases low-blood-pressure risk.

Prescription required in the U.S.; a clinician must assess suitability and choose the dose. Never combine with nitrates, nitrite 'poppers', or riociguat. Review heart health, kidney/liver disease, alpha-blockers, blood-pressure medicines and CYP3A4 interactions. Do not combine ED medicines. Get emergency care for an erection lasting over 4 hours; stop use and seek prompt care for sudden vision/hearing loss. For chest pain during sex, stop and get urgent care; tell responders when the last dose was taken.

Available as 25, 50 and 100 mg tablets. The usual label starting dose is 50 mg about 1 hour before sex; dosing can be adjusted by the prescriber. The timing range is 30 minutes to 4 hours beforehand, no more than once daily for most patients. High-fat meals can delay onset. Sexual stimulation is needed. Common adverse effects include headache, flushing, indigestion, nasal congestion and visual changes.

Prescription required in the U.S.; a clinician must assess suitability and choose the dose. Never combine with nitrates, nitrite 'poppers', or riociguat. Review heart health, kidney/liver disease, alpha-blockers, blood-pressure medicines and CYP3A4 interactions. Do not combine ED medicines. Get emergency care for an erection lasting over 4 hours; stop use and seek prompt care for sudden vision/hearing loss. For chest pain during sex, stop and get urgent care; tell responders when the last dose was taken.